Как искать в интернете достоверную медицинскую информацию

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    Shanmugam N, Scott JX, Kumar V, Vij M, Ramachandran P, Narasimhan G, Reddy MS, Kota V, Munirathnam D, Kelgeri C, Sundaram K, Rela M.
    Shanmugam N, et al.
    Pediatr Blood Cancer. 2017 Mar;64(3). doi: 10.1002/pbc.26249. Epub 2016 Oct 26.
    Pediatr Blood Cancer. 2017.

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  • New concepts and outcomes for children with hepatoblastoma based on the experience of a tertiary center over the last 21 years.

    Tannuri AC, Cristofani LM, Teixeira RA, Odone Filho V, Tannuri U.
    Tannuri AC, et al.
    Clinics (Sao Paulo). 2015 Jun;70(6):387-92. doi: 10.6061/clinics/2015(06)01. Epub 2015 Jun 1.
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  • Survival after liver transplantation for hepatoblastoma: a 2-center experience.

    Browne M, Sher D, Grant D, Deluca E, Alonso E, Whitington PF, Superina RA.
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  • Fetal and neonatal hepatic tumors.

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  • Efficacy of neoadjuvant therapy and surgical rescue for locally advanced hepatoblastomas: 10 year single-center experience and literature review.

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Alternative interfaces

MEDLINE is one of the databases which are accessible via PubMed. Several companies provide access to MEDLINE through their platforms.

The National Library of Medicine leases the MEDLINE information to a number of private vendors such as Embase, Ovid, Dialog, EBSCO, Knowledge Finder and many other commercial, non-commercial, and academic providers. As of October 2008, more than 500 licenses had been issued, more than 200 of them to providers outside the United States. As licenses to use MEDLINE data are available for free, the NLM in effect provides a free testing ground for a wide range of alternative interfaces and 3rd party additions to PubMed, one of a very few large, professionally curated databases which offers this option.

Lu identifies a sample of 28 current and free Web-based PubMed versions, requiring no installation or registration, which are grouped into four categories:

  1. Ranking search results, for instance: eTBLAST; MedlineRanker; MiSearch;
  2. Clustering results by topics, authors, journals etc., for instance: Anne O’Tate; ClusterMed;
  3. Enhancing semantics and visualization, for instance: EBIMed; MedEvi.
  4. Improved search interface and retrieval experience, for instance, askMEDLINE BabelMeSH; and PubCrawler.

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  • Application of photodynamic therapy for liver malignancies.

    Zou H, Wang F, Zhou JJ, Liu X, He Q, Wang C, Zheng YW, Wen Y, Xiong L.
    Zou H, et al.
    J Gastrointest Oncol. 2020 Apr;11(2):431-442. doi: 10.21037/jgo.2020.02.10.
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  • LIN28B gene polymorphisms modify hepatoblastoma susceptibility in Chinese children.

    Yang Z, Deng Y, Zhang K, Bai Y, Zhu J, Zhang J, Xin Y, Li L, He J, Wang W.
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    J Cancer. 2020 Mar 15;11(12):3512-3518. doi: 10.7150/jca.42798. eCollection 2020.
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    Li L, Zhuo Z, Yang Z, Zhu J, He X, Yang Z, Zhang J, Xin Y, He J, Zhang T.
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  • m6A mRNA methylation regulates CTNNB1 to promote the proliferation of hepatoblastoma.

    Liu L, Wang J, Sun G, Wu Q, Ma J, Zhang X, Huang N, Bian Z, Gu S, Xu M, Yin M, Sun F, Pan Q.
    Liu L, et al.
    Mol Cancer. 2019 Dec 23;18(1):188. doi: 10.1186/s12943-019-1119-7.
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Data mining of PubMed

Alternative methods to mine the data in PubMed use programming environments such as Matlab, Python or R. In these cases, queries of PubMed are written as lines of code and passed to PubMed and the response is then processed directly in the programming environment. Code can be automated to systematically queries with different keywords such as disease, year, organs, etc. A recent publication (2017) found that the proportion of cancer-related entries in PubMed has risen from 6% in the 1950s to 16% in 2016.

The data accessible by PubMed can be mirrored locally using an unofficial tool such as MEDOC.

Millions of PubMed records augment various open data datasets about open access, like Unpaywall. Data analysis tools like Unpaywall Journals are used by libraries to assist with big deal cancellations: libraries can avoid subscriptions for materials already served by instant open access via open archives like PubMed Central.

What’s New

Visit our What’s New page to see all recent MeSH developments including the most recent ones listed below

  • 2020 MeSH files are now in production

    • The MeSH Browser now displays 2020 MeSH and 2019 MeSH vocabularies
    • Reports of MeSH changes are available from our What’s New page
    • All 2020 MeSH files are now available via FTP download
  • MeSH in Resource Description Format(RDF) is now in production

    • The downloadable files contain a full representation of XML MeSH in RDF format
    • An open MeSH API is available for retrieving MeSH data
    • You can use our SPARQL query editor for querying MeSH data
  • MeSH on Demand 2.0 has been re-engineered and improved in response to your suggestions.

    • Matching MeSH terms are now highlighted in response to your submitted text
    • MeSH headings now include links to scope notes
    • Custom PubMed searches are more easily made
    • Term expansion and tree-based searching features have been added
    • You can now display of similar article titles from PubMed

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  • Role of environmental factors & oxidative stress with respect to in vitro fertilization outcome.

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  • Time Restriction of Food Intake During the Circadian Cycle Is a Possible Regulator of Reproductive Function in Postadolescent Female Rats.

    Fujiwara T, Nakata R, Ono M, Mieda M, Ando H, Daikoku T, Fujiwara H.
    Fujiwara T, et al.
    Curr Dev Nutr. 2018 Nov 26;3(4):nzy093. doi: 10.1093/cdn/nzy093. eCollection 2019 Apr.
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  • Epidemiologic Factors Associated with Endometriosis in East Asia.

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    Review.

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    J Infect Dis. 2020 Jun 16;222(1):26-33. doi: 10.1093/infdis/jiaa211.
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Content

In addition to MEDLINE, PubMed provides access to:

  • older references from the print version of Index Medicus, back to 1951 and earlier
  • references to some journals before they were indexed in Index Medicus and MEDLINE, for instance Science, BMJ, and Annals of Surgery
  • very recent entries to records for an article before it is indexed with Medical Subject Headings (MeSH) and added to MEDLINE
  • a collection of books available full-text and other subsets of NLM records
  • PMC citations

Many PubMed records contain links to full text articles, some of which are freely available, often in PubMed Central and local mirrors, such as Europe PubMed Central.

Information about the journals indexed in MEDLINE, and available through PubMed, is found in the NLM Catalog.

As of 27 January 2020, PubMed has more than 30 million citations and abstracts dating back to 1966, selectively to the year 1865, and very selectively to 1809. As of the same date, 20 million of PubMed’s records are listed with their abstracts, and 21.5 million records have links to full-text versions (of which 7.5 million articles are available, full-text for free). Over the last 10 years (ending 31 December 2019), an average of nearly 1 million new records were added each year. Approximately 12% of the records in PubMed correspond to cancer-related entries, which have grown from 6% in the 1950s to 16% in 2016.
Other significant proportion of records correspond to «chemistry» (8.69%), «therapy» (8.39%), and «infection» (5%).[citation needed]

In 2016, NLM changed the indexing system so that publishers are able to directly correct typos and errors in PubMed indexed articles.

PubMed has been reported to include some articles published in predatory journals. MEDLINE and PubMed policies for the selection of journals for database inclusion are slightly different. Weaknesses in the criteria and procedures for indexing journals in PubMed Central may allow publications from predatory journals to leak into PubMed.

Abstract

Hepatoblastoma is the most common primary malignant hepatic tumor of infancy and childhood, occurring predominantly in the first two years of life. The management of hepatoblastoma has changed markedly over the last 3 decades; neoadjuvant chemotherapy is now standard, particularly in unresectable tumors resulting in considerable preoperative tumor shrinkage and sometimes near total ablation of the tumor. A 20 month old infant was incidentally found to have a 7.6cm right sided retroperitoneal tumor on routine screening ultrasonography for left ureteral stenosis. Serum alpha fetoprotein was elevated. Biopsy revealed hepatoblastoma, mixed epithelial and embryonal type without mesenchymal elements. He underwent neoadjuvant chemotherapy. Although the tumor had decreased considerably in size, close proximity to major vascular structures precluded safe resection. Liver transplantation was performed; the explanted liver showed complete tumor necrosis with no residual malignancy. The postoperative course was uncomplicated and he is continuing on sixth cycle of chemotherapy.

How to access TOXNET information

Comprehensive Toxicology Information

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Toxicology Literature

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Breastfeeding & Drugs

Help for LactMed Users in Bookshelf (PDF)Help for LactMed Users in Bookshelf (Web Page)

Chemical Information

Help for ChemIDplus Users in PubChem (PDF) Help for ChemIDplus Users in PubChem (Web Page)

Developmental Toxicology Literature

Help for DART Users in PubMed (PDF) Help for DART Users in PubMed (Web Page)

Drug-Induced Liver Injury LiverTox in Bookshelf LiverTox has been migrated to BookShelf
Chemical Releases & Mapping TOXMAP was retired.

Underlying data remains accessible through their original resources: Government of Canada National Pollutant Release Inventory (NPRI), U.S. Census Bureau, U.S. EPA Clean Air Markets Program, U.S. EPA Geospatial Applications, U.S. EPA Facilities Registry System (FRS) , U.S. EPA Superfund Program, U.S. EPA Toxics Release Program (TRI), U.S. NIH NCI Surveillance, Epidemiology, and End Results Program (SEER), U.S. Nuclear Regulatory Commission (NRC)

GIS application users can overlay the data in their own GIS applications.

Comparative Toxicogenomics TOXNET’s CTD was retired. Visit CTD at NC State University.
Household Product Safety The content of HPD is available from the original content provider Consumer Product Information Database https://www.whatsinproducts.com/
Occupational Exposure To Chemicals HazMap was retired. The content of Haz-Map is still provided by the original content provider
Dietary Supplement Information

Dietary Supplement Ingredient Database (DSID): The Dietary Supplement Ingredient Database (DSID) (https://dsid.od.nih.gov) provides estimated levels of ingredients in dietary supplement products sold in the United States. These statistically predicted estimates may differ from labeled amounts and are based on chemical analysis of nationally representative products. This site is now being updated and maintained for access by the NIH Office of Dietary Supplements

Dietary Supplement Label Database (DSLD): The Dietary Supplement Label Database (DSLD) (https://dsld.od.nih.gov) includes full label derived information from dietary supplement products marketed in the U.S. with a Web-based user interface that provides ready access to label information. This site is now being updated and maintained for access by the NIH Office of Dietary Supplements

Risk Assessment TOXNET’s IRIS was retired. Visit IRIS at EPA. TOXNET ITER: The content of ITER will be available from the original content provider Toxicology Excellence for Risk Assessment Database http://www.iter.tera.org/
Animal Testing Alternatives ALTBIB
Archived, No Longer Updated

Help for CCRIS Users in PubChem (PDF) Help for CCRIS Users in PubChem (Web Page)

CPDB was retired. Access CPDB data at https://www.toxinfo.io and from the EPA at https://www.epa.gov/chemical-research/distributed-structure-searchable-toxicity-dsstox-database

Help for GENE-TOX Users in PubChem (PDF)Help for GENE-TOX Users in PubChem (Web Page)

Archived Publications

  • 2014 DailyMed/RxNorm Jamboree Workshop Last updated: September 29, 2014
  • 2015 DailyMed/RxNorm Jamboree Workshop Last updated: October 14, 2015
  • 2016 DailyMed/RxNorm Jamboree Workshop Last updated: November 11, 2018
  • 2017 DailyMed/RxNorm Jamboree Workshop Last updated: November 11, 2018
  • Alphabetic Listing of MeSH Last updated: December 6, 2016
  • Changed Descriptors — 2015 Last updated: October 30, 2018
  • Changes in ASCII MeSH Format Last updated: April 9, 2016
  • Deleted Descriptors — 2018 Last updated: January 6, 2017
  • Files Available to Download Last updated: November 29, 2018
  • MeSH Qualifiers with Scope Notes Last updated: June 13, 2017
  • MeSH Staff Presentations and Publications Last updated: June 22, 2016
  • MeSH Staff Presentations and Publications (Archive) Last updated: April 24, 2013
  • SPL/DailyMed Jamboree Workshop 2013 Last updated: December 3, 2016
  • Use of Medical Subject Headings For Cataloging Last updated: October 29, 2019

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  • Lifestyle factors and reproductive health: taking control of your fertility.

    Sharma R, Biedenharn KR, Fedor JM, Agarwal A.
    Sharma R, et al.
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  • .

    Zavos PM.
    Zavos PM.
    Fertil Contracept Sex. 1989 Feb;17(2):133-8.
    Fertil Contracept Sex. 1989.

    PMID: 12281878

    French.

  • Knowledge about infertility risk factors, fertility myths and illusory benefits of healthy habits in young people.

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    Hum Reprod. 2008 Aug;23(8):1858-64. doi: 10.1093/humrep/den168. Epub 2008 May 10.
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The expertise of the group is concentrated in sequence analysis, protein structure/function analysis, chemical informatics, and genome analysis. Research interests further cover a wide range of topics in computational biology and information science. These include, but are not limited to, database searching algorithms, sequence signal identification, mathematical models of evolution, statistical methods in virology, dynamic behavior of chemical reaction systems, statistical text-retrieval algorithms, protein structure and function prediction, comparative genomics, taxonomic trees, population genetics, and systems biology.

Many of the basic research projects conducted by CBB investigators serve to enhance and strengthen NCBI’s suite of publicly available databases and software application tools. Collaborative research efforts, among NCBI investigators as well as with the external research community, have led to the development of innovative algorithms (BLAST, PSI-BLAST, VAST, and COGs), novel research approaches (text neighboring) and fundamental resources (PubChem and CDD) that have transformed the field of computational biology. Algorithms and applications currently under development have the potential to further advance scientific discovery.

Members of the CBB contribute significantly to the validity and reliability of NCBI’s online resources by reviewing the quality and accuracy of the data deposited in the databases, as well as the accuracy of the information used to annotate the data. Members also provide leadership and guidance to the extramural community by planning and organizing scientific consortia to determine the most effective use of public sequence resources for large-scale or high-throughput experimental biology. Researchers collaborate to define new areas of research and identify appropriate computational mechanisms to address them.

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Cited by 248 articles

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    PMID: 32656223
    Free PMC article.

  • The Anatomic Pathology laboratory adjustments in the era of COVID-19 pandemic: The experience of a laboratory in a Portuguese central hospital.

    Lamas NJ, Esteves S, Alves JR, Costa FE, Tente D, Fonseca P, Vizcaíno JR.
    Lamas NJ, et al.
    Ann Diagn Pathol. 2020 Jul 1;48:151560. doi: 10.1016/j.anndiagpath.2020.151560. Online ahead of print.
    Ann Diagn Pathol. 2020.

    PMID: 32645559
    Free PMC article.

  • The experience of women infected by the COVID-19 during pregnancy in Brazil: a qualitative study protocol.

    Freitas-Jesus JV, Rodrigues L, Surita FG.
    Freitas-Jesus JV, et al.
    Version 2. Reprod Health. 2020 Jul 8;17(1):108. doi: 10.1186/s12978-020-00958-z.
    Reprod Health. 2020.

    PMID: 32641133
    Free PMC article.

  • Chopping the tail: how preventing superspreading can help to maintain COVID-19 control.

    Kain MP, Childs ML, Becker AD, Mordecai EA.
    Kain MP, et al.
    medRxiv. 2020 Jul 3:2020.06.30.20143115. doi: 10.1101/2020.06.30.20143115. Preprint.
    medRxiv. 2020.

    PMID: 32637966
    Free PMC article.

Выводы

Чему можно доверять:

  • сайту Министерства здравоохранения Российской Федерации (стандартам оказания медицинской помощи и критериям оценки качества оказания медицинской помощи);
  • клиническим рекомендациям Министерства здравоохранения Российской Федерации;
  • сайтам с инструкциями к лекарственным препаратам (Vidal, РЛС, «ЛС ГЭОТАР»);
  • электронным медицинским базам данных;
  • сайтам ВОЗ и Роспотребнадзора.

Чего лучше избегать:

  • обсуждений на форумах;
  • статей в «Википедии»;
  • рекламных материалов;
  • публикаций без ссылок на источники доказательной медицины.

Искать информацию о здоровье можно и нужно — но только на «правильных» сайтах с достоверными данными. И конечно, всегда помните, что врач в лечении ориентируется не только на стандарты и критерии качества, но и на свой опыт и особенности пациента.

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