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Departments of Pathology and Obstetrics-Gynecology and Reproductive Science, The Mount Sinai-NYU Medical Center, New York, New York Correspondence: Liane Deligdisch, M.D., Mount Sinai Medical Center, Department of Pathology, One Gustave Levy Place, New York, NY 10029. The endometrial tissue is a sensitive target for steroid sex hormones and is able to modify its structural characteristics with promptness and versatility.I am a mother of three, part-time doctor, full-time wife and mother. My patients often come to the clinic for medical concerns but we always end up discussing all sorts of things like marital issues, family life, vacation spots, shopping and dining out. The information I will provide are my personal opinions and ideas based on research, seminars attended and first-hand experience.
This article discusses briefly endogenous hormonal effects (cyclic changes, luteal phase defect, unopposed estrogen effect) and describes the histologic patterns encountered in the most commonly used hormone therapies: oral contraceptives, ovulation stimulation, hormone replacement therapy, and antitumoral hormone therapy.
Oral contraceptives exert a predominant progestational effect on the endometriun, inducing an arrest of glandular proliferation, pseudosecretion, and stromal edema followed by decidualized stroma with granulocytes and thin sinusoidal blood vessels.
Prolonged use results in progressive endometrial atrophy.
Ovulation induction therapy accelerates the maturation of the stroma and is often associated with a discrepancy between early secretory glands and an edematous or decidualized stroma with spiral arterioles.
Progesterone therapy for endometrial hyperplasia and neoplasia induces glandular secretory changes, decidual reaction, and spiral arterioles.
Glandular proliferation is usually arrested, but neoplastic changes may persist and coexist with secretory changes.The vacuoles will be supranuclear in midsecretary phase.In the late secretary phase, the glands are saw toothed and serrated with luminal secretions Stroma: the stromal cells which were spindle shaped in proliferative cells, are now enlarged.Morphologically, the endometrium is one of the most dynamic target tissues in women.Its cyclic structural changes mirror changes in metabolic functions, and both are regulated by ovarian estradiol and progesterone. Schematic representation of steroid hormone-morphologic interactions during the endometrial cycle.The nuclei rather than centrally-located are pseudostratified, though they tend to be found in the basal half.Tags: Adult Dating, affair dating, sex dating